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Some cases are recorded, but there are a few things to consider

[DOI] [PMC free article] [PubMed] [Google Scholar] Kamoun P, Belardinelli MC, Chabli A, Lallouchi K, ChadefauxVekemans B (2003)

Although genetic engineering can endow bacterial strains with specific therapeutic functions, engineered live bacteria still face certain biosafety issues when entering the host or environmental system